Mifeprex (mifepristone) Tablets: 3 Proven Medical Uses & Safety Guide

Mifeprex (mifepristone) Tablets – Medical Use & Important Safety Information

Mifepristone is a prescription medication used for specific medical indications under strict medical supervision. It is most commonly used in combination with misoprostol for the termination of early pregnancy (up to 70 days) and is also approved for the management of hypercortisolism-related hyperglycemia in patients with Cushing’s syndrome.

How Mifepristone Works

Mifepristone works by blocking the hormone progesterone, which is necessary to maintain the uterine lining during pregnancy. Without progesterone support, the uterus cannot sustain the pregnancy, and expulsion occurs after follow-up treatment with misoprostol. In patients with Cushing’s syndrome, mifepristone helps control high blood sugar levels caused by excess cortisol when surgery is not possible or has failed.

Approved Uses

• Medical termination of pregnancy up to 70 days, when used with misoprostol
• Control of hyperglycemia in adults with Cushing’s syndrome

Dosage & Administration

For Termination of Pregnancy

• Day 1: One 200 mg tablet of mifepristone taken orally
• 24–48 hours later: 800 mcg of misoprostol (four 200 mcg tablets), placed in the cheek pouches
• Follow-up with a healthcare provider is required within 7–14 days

For Hyperglycemia in Cushing’s Syndrome

• Starting dose: 300 mg once daily with food
• Maximum dose: up to 1200 mg per day, as prescribed by a doctor

Important Safety Information for Mifeprex (mifepristone)

This medication is available only by prescription and is distributed under the Mifepristone REMS Program. It must be used exactly as directed by a qualified healthcare professional.

• Not suitable for ectopic pregnancy
• May cause heavy vaginal bleeding and cramping
• Regular medical follow-up is essential
• Avoid grapefruit and grapefruit juice during treatment

Mifeprex (mifepristone) Possible Side Effects

Common side effects may include nausea, dizziness, headache, abdominal pain, fatigue, and vaginal bleeding. Serious side effects such as infection, excessive bleeding, adrenal gland issues, or heart rhythm changes require immediate medical attention.

Storage Instructions

• Store at room temperature
• Keep away from moisture, heat, and direct light
• Keep out of reach of children

Disclaimer: This product must only be used under medical supervision. Always consult your doctor before use.